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KMID : 0370220030470060398
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Yakhak Hoeji
2003 Volume.47 No. 6 p.398 ~ p.403
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Effects of Phenylpropanoid Compounds on Melanin Production in B16 Melanoma Cells
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박영미/Park YM
윤미연/김경원/조남영/임혜원/이지윤/이진희/김연정/Yoon MY/Kim KW/Cho NY/Lim HW/Lee JY/Lee JH/Kim YJ
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Abstract
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To investigate the relationship between structure and bioological activity of phenylpropanoids, we measured effects of phenylpropanoids on anti-oxidant activity. Although phen ylpropanoids did not inhibit purified-tyrosinase activity, they significantly inhibited tyrosinase activity and melanin production in MSH-stimulated B16 melanoma cells. However, phenylpropanoids did not affect tyrosinase expression in MSH-stimulated B16 melanoma cells, which suggest that inhibition of MSH-induced melanin production was due to tyrosinase inhibition mediated via other signal pathways but not expression of tyrosinase. Phenylpropanoids also significantly inhibited both hyaluronidase and elastase activity, suggesting that phenylpropanoids plays an important role in anti-oxidant and whitening activity.
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KEYWORD
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